Release of nifedipine, furosemide, and niclosamide drugs from the biocompatible poly(HEMA) hydrogel structures

The primary aim of this article was to improve the solubility and bioavailability drugs nifedipine, niclosamide, furosemide due their poor dissolution rate. Therefore, these require improvement in rate formulation development, especially solid dosage forms such as hydrogels capsules. Hydrogel structures were synthesized by using a biocompatible, nontoxic, protective pure 2-hydroxy ethyl methacrylate (HEMA) monomer. These hydrogel characterized various techniques scanning electron microscopy Fourier-transformed infrared spectroscopy. In next step, drug molecules loaded poly hydrogels. Drug releases drug-loaded measured at certain time intervals recorded cumulatively (%). pH affinity, morphology, structure, release, swelling, cytotoxic effect resulting materials studied detail. addition investigating biocompatibility cytotoxicity hydrogel, we evaluated an vitro assay on MCF-7and MIA PaCa-2 HEK 293 cell lines with structure confirmed viability over 85%. results suggest that our HEMA polymeric is material biological importance great pharmacological potential supporting release furosemide, similar molecules.